306 Xinsha Road, Shajing Street, Bao'an District,Shenzhen, Guangdong, China
خانه محصولاتCancer Treatment Steroids

Nintedanib 928326-83-4 (BIBF 1120) Fibrosis Pharmaceutical Powder of The Lungs Treatment

Nintedanib 928326-83-4 (BIBF 1120) Fibrosis Pharmaceutical Powder of The Lungs Treatment

    • Nintedanib 928326-83-4 (BIBF 1120) Fibrosis Pharmaceutical Powder of The Lungs Treatment
    • Nintedanib 928326-83-4 (BIBF 1120) Fibrosis Pharmaceutical Powder of The Lungs Treatment
    • Nintedanib 928326-83-4 (BIBF 1120) Fibrosis Pharmaceutical Powder of The Lungs Treatment
    • Nintedanib 928326-83-4 (BIBF 1120) Fibrosis Pharmaceutical Powder of The Lungs Treatment
  • Nintedanib 928326-83-4 (BIBF 1120) Fibrosis Pharmaceutical Powder of The Lungs Treatment

    جزئیات محصول:

    Place of Origin: China
    نام تجاری: Sendi
    گواهی: SGS,ISO9001
    Model Number: 928326-83-4

    پرداخت:

    Minimum Order Quantity: 10 Grams
    قیمت: 1.5 usd dollars per gram
    Packaging Details: Discreet and safe foil bag
    Delivery Time: Within 12hours after payment
    Payment Terms: West Union, T/T, Money Gram.,Bitcorn and bank transfer, D/P
    Supply Ability: 10000 Kg
    اکنون تماس بگیرید
    توضیحات محصول جزئیات
    Name: Nintedanib CAS: 928326-83-4
    MF: C31H33N5O4 Description: White powder
    Grade Standard: Pharmaceutical grade Other name: BIBF 1120
    Assay: 99% Category: Cancer Treatment Steroids

    Nintedanib 928326-83-4 (BIBF 1120) Fibrosis Pharmaceutical Powder of The Lungs Treatment

     

    Product name Nintedanib
    CAS NO. 656247-17-5
    Synonyms Nintedanib
    Category Pharmaceutical Raw Materials,Active Pharmaceutical Ingredients,Bulk Drugs,Fine Chemicals.
    Standard purity:>99%
    Appearance Nintedanib powder
    Shelf life 2 years
    Usage Nintedanib is used to treat some types of non-small-cell lung cancer and for idiopathic pulmonary fibrosis.
    Storage Nintedanib should be stored in a well-closed container at low temperature, keep away from moisture, heat and light.

     

    Grade Standard: Pharmaceutical grade Purity: 98%
    Place of Origin:China

    Description:


    1. Nintedanib is a medication used for the treatment of idiopathic pulmonary fibrosis (IPF) and along with other medications for some types of non-small-cell lung cancer.

    2. Common side effects include abdominal pain, vomiting, and diarrhea.It is a small molecule tyrosine-kinase inhibitor, targetingvascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR) and platelet derived growth factor receptor (PDGFR).

    3. It's dveloped by Boehringer Ingelheim. At an assumed cost of 39,300 pounds per year it does not appear to be cost effective for IPF in the United Kingdom.


    Application:

     

    1. Nintedanib BIBF (1120) is a kind of effective triple vessel kinase inhibitor, on VEGFR1 / two-thirds, FGFR1/2/3 and PDGFR alpha/beta has inhibitory effect on the IC50 of 34 nM / 13 nM / 13 nM respectively, 37 nM / 69 nM / 69 nM and 59 nM / 65 nM. Phase 2.BIBF1120 inhibits PDGFR kinase activity of PDGFR alpha and PDGFR beta types with IC50 values of 59 nM and 65 nM, respectively.

     

    2. In addition, BIBF1120 suppresses the FGFR subtypes with IC50 of 60 nM, 37 nM and 108 nM for FGFR1, FGFR2, and FGFR3, respectively. BIBF1120 binds to the ATP-binding site in the cleft between the amino and carboxy terminal lobes of the kinase domain.

     

    3. The indolinone scaffold forms two hydrogen bonds with the backbone nitrogen of Cys919 and the backbone carbonyl oxygen of Glu917 in the hinge region.

     

    4. IBF 1120 inhibits proliferation of PDGF-BB stimulated BRPs with EC50 of 79 nM in cell assays. BIBF1120 at concentrations as low as 100 nM blocks activation of MAPK after stimulation with 5% serum plus PDGF-BB.

     

    5. In cultures of human vascular smooth muscle cells (HUASMC), BIBF1120 prevents PDGF-BB stimulated proliferation with an EC50 of 69 nM.

    a. In food additives field
    b. In cosmetics field
    c. In pharmaceutical field

    Nintedanib COA:

     

    Item Index
    Supreme grade First grade
    Color, pt-Co scale ≤ 10 20
    Purity, %(m/m) ≥ 99.9 99.7
    Benzene content, mg/kg ≤ 50 100
    n-Hexane content, mg/kg ≤ 200 500
    Methyl cyclohexane content, mg/kg ≤ 200 500
    Methyl cyclopentane content, mg/kg ≤ 150 400
    Distillation range at 101.3kPa,
    Including 80.7° C, ° C ≤
    1 1.5
    Sulphur content, mg/kg ≤ 1 2
    Nonvolatile content, mg/ 100ml ≤ 1 5
    Density, 20° C, km/m3 0.777-0.782


    *************************************************************************************************************************************
    Package details:
    1kg/Aluminum foil bag
    1kg/ Aluminium Tin
    25kg/Drum
    25kg/ Aluminum Drum
    *************************************************************************************************************************************
    Delivery Time:
    Usually within 2 working days after confirming the payment.
    *************************************************************************************************************************************
    Shipping details:
    DHL; TNT; UPS or EMS

    *************************************************************************************************************************************
    Hot sales products:

     

    Acitretin Budesonide
    Isotretinoin Vecuronium bromide
    Tretinoin 16alpha-Hydroxyprednisonlone acetate
    Finasteride N-(n-butyl)-thiophosphoric triamide
    Dutasteride Methyl 3-oxo-4-androstene-17beta-carboxylate
    Guggulsterones E&Z 4-Androsten-3-one-5-ene-17-carboxylic acid
    Deflazacort METHYL 4-AZA-5ALPHA-ANDROSTA-3-ONE-17BETA-CARBOXYLATE
    Meprednisone Dihydroproscar

     

    Our commitment:

    1. Any inquiries will be replied within 12 hours.
    2. Dedication to quality, supply & service.
    3. Strictly on selecting raw materials.
    4. OEM/ODM Available.
    5. Reasonable & competitive price, fast lead time.
    6. Sample is available for your evaluation & Formulation development.
    7. Faster delivery:Sample order in stock and 3-7 days for bulk production.
    8. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.
    9. After-Sale Service:
    (1) International Authorized Third-Party Test For The Products You Demand.
    (2) 60 Days Warranty of quality of goods.

    Nintedanib 928326-83-4 (BIBF 1120) Fibrosis Pharmaceutical Powder of The Lungs Treatment

     

    We also supply

     

    Hot sell Oral Products Oxan drolone (Anavar)
    Oxy metholone (Anadrol)
    Stano zolol (Winstrol)
    Dianabol(Methandrostenolone)
    Testos terone Test Base
    Test Enanthate
    Test Acetate
    Test Propionate Test Phenylpropionate
    Test Isocaproate Test Cypionate Test Sustanon 250
    Test Decanoate
    Test Undecanoate
    1-Testos terone
    1-Testos terone Cypionate
    17-methyltestostero(methyl testos terone)
    17α-Methyl-Testos terone
    Oral turinabol(4-Chlorodehydromethyltestosterone)
    Turinabol(Chloroterone Acetate,Clostebol Acetate)
    Hexadrone
    Mestero lone(Proviron)
      Nan drolone
    Nan drolone Propionate
    Nan drolone Decanoate(DECA)
    Nan drolone Phenypropionate
    Me stanolone
    Nan drolone Undecanoate
    Nan drolone Cypiontate

    Stanolone (DHT)
    Bolde none Bolde none base
    Bolde none Propionate
    Bolde none Undecylenate(Equipoise)
    Bolde none cypiontate
    Bolde none Acetate
    Tren bolone Tren bolone base
    Tren bolone acetate (Finaplix)
    Tren bolone enanthate (Parabolan)
    Tren bolone hexahydrobenzyl Carbonate
    Ti bolone
    Methylstenbolone
      Dros tanolone Propionate (Masteron p)
    Methenolone Methenolone Enanthate Methenolone Acetate
    DH EA DH EA
    (Dehy droepiandrosterone)
    1-DH EA
    4-DH EA
    7-Keto-DH EA
    Epiandrosterone
    Epiandrosterone Acetate
    Others Methyl dienedione
    Trendione/Trenavar
    6-OXO
    11-OXO
    Epistane/Methyl Epitiostanol
    2
    Androstatrienedione
    2, 4-Dinitrophenol
    Dustasteride
    Des onide
    Tria mcinolone
    Finasteride
    Cytomel, T3
    L-Thyroxine, T4
    Rimonabant
    L-Carnitine
    Sex Enhancer Flibanserin
    Cia lis (Tadalafil)
    Via gra (Silde nafil) Vardenafil (Le vitra)
    Acetildenafil (Hongdenafil)
    Yohimbine Hcl

    Maca Extract
    Pain Killer Benzocaine / Benzocaine hcl
    Procaine / Procaine Hcl
    Lidocaine HCL
    Tetracaine / Tetracaine HCL
    Bupivacaine/ Bupivacaine HCL
    Articaine / Articaine hcl
    Anti-Estrogen Tamoxifen Citrate (Nolvadex)
    Clomiphene citrate (Clomid)
    Exe mestane(Aromasin)
    Ana strozole (Arimidex) Letrazole(Femara / For mestane)
    Pharmaceuticals Phe nacetin

    Dexamethasone Sodium Phosphate
    Paracetamol
    Pregabalin
    Raloxifene HCL
    Theophylline
    Fura zabol THP
    Atorvastatin Calcium
    Lorcaserin
    Carbergoline
    .......And ect
    Safe Organic Solvents Gamma-Butyrolactones(GBLsolvents )
    1,4-Butanediol(BDO)
    Ethyl Oleate(EO)
    Grape Seed Oil(GSO)
    Benzyl Alcohol(BA)
    Benzyl benzoate(BB)
    Guaiacol
    Poly Ethylene Glycol(PEG)
    Polysorbate 80
    H G H&Peptides H G H 176-191 2mg/vial
    MGF PEG MGF
    CJC-1295 / with DAC
    PT-141 10mg/vial
    MT-1 MT-2 10mg/vial
    GHRP-2 5mg/vial & 10mg/vial
    GHRP-6 5mg/vial & 10mg/vial
    Ipamorelin 2mg/vial
    Hexarelin 2mg/vial
    Sermorelin 2mg/vial
    Selank 5mg/vial
    Follistatin 344
    Follistatin 315
    Eptifibatide
    SARMs Aicar
    Andarine / S4
    Andarine / GTX-007
    GW-501516(cardarine)
    LGD-4033
    MK-677/Ibutamoren/Nutrobal
    MK-2866/Ostarine/Enobosarm
    RAD-140
    SR9011
    SR9009
    Sunifiram
    YK11

     

    اطلاعات تماس
    Shenzhen Sendi Biotechnology Co.Ltd.

    تماس با شخص: Demi

    تلفن: +8618123940985

    ارسال درخواست خود را به طور مستقیم به ما (0 / 3000)

    سایر محصولات